12 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... Demyelinating Syndrome ... Cerebrovascular Disease ... inflammation, leading ... permeability Diagnosis
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
commonly through its ... Rarely dominate the clinical ... Differential Diagnosis ... • Goodpasture syndrome ... #rash #diagnosis
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... Alpha & Mu) Skin ... thrombosis+Pulm HTN+skin ... to cold IgG • Lupus ... #Differential #Diagnosis
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... 3rd Decade Skin ... Differential Diagnosis ... Clinical Features ... Seizures • Strokes Skin
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... Positive Coombs testing ... post infectious setting ... hemolytic #anemia #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
IL-1 and IL-6, leading ... • Systemic lupus ... nervous system (CNS ... SJIA], systemic lupus ... #Diagnosis #Management
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
immune system, leading ... - Purpura - Skin ... : • Clinical triad ... • Autoimmune diseases ... (e.g. systemic lupus
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
on bone marrow leading ... extramedullary disease ... • Tumor lysis syndrome ... CLL -> Invade Skin ... #Oncology #Diagnosis
Cutaneous larva migrans skin Rash
25 F recent Caribbean vacation, walked barefoot on sand and now with
with creepy rash. diagnosis ... is clinical & labs ... effective, and its ... migrans #skinRash #dermatology ... #clinical #photo
Helpful Clinical Features in Evaluating Bleeding Disorders
Age of onset
 • Neonate - in 20% of haemophilias,
Helpful Clinical ... membrane bleeding and skin ... Marfan syndrome, ... peds #pediatrics #diagnosis ... #hematology #primarycare