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diagnosis hematology management causes hemolytic agglutinin classification cvid disease erythematosus extravascular gap globulin hypogammaglobulinemia immunodeficiency immunology intravascular lung lupus lymphoma
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... lymphoproliferative disorders ... disease, Copper and ... Extravascular #Causes #differential ... #anemia
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral infection, autoimmune ... symptoms - most common ... anemia • Cold ... younger pts) Differential ... #anemia #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Immunosuppression • Autoimmune ... disorders Hodgkin ... nodosum • Immune hemolytic ... anemia • Pain ... Immunohistochemical studies (to differentiate
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... Lymphoma or other cancers ... cancer Granulomatous ... autoimmune hemolytic ... anemia) • Systemic
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
infection • Most common ... Leukocytosis, anemia ... foreign body, cancer ... Coli - P. ... Differential Diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... lymphopenia, low PLT • Anemia ... Kidney disease common ... cyclophosphamide) • Hodgkin ... • Lung cancer
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Connective tissue disorders ... Cirrhosis, ETOH, autoimmune ... ovarian tumors, lung cancers ... Comment on type ... Gap #ProteinGap #differential
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