11 results
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Thrombocytopenia: ITP ... OF PALPABLE PURPURA ... Ig A vasculitis/HSP ... #rheumatology #
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... purpura (16%) ... purpura • Vesicles ... overlying purpuric ... Henoch-Schönlein purpura
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm
Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... Thrombocytopenia • Idiopathic ... thrombocytopenic purpura ... thrombocytopenic purpura ... von Willebrand's disease
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis: • Purpura ... purpura: Strong ... purpura • Pauci ... purpura, joint ... purpura (lower
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... thrombocytopenic purpura ... (TTP), Hemolytic ... CLL, lymphoma, idiopathic ... Extravascular #Causes
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
easy bruising to purpura ... (Petechial or purpuric ... 5000 to 10,000 ng/mL ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Arthralgia - Purpura ... Clinical triad of Palpable ... purpura, Arthralgia ... • Autoimmune diseases ... Henoch-Schönlein purpura
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Petechiae • Purpura ... • Palpable variants ... Hemorrhagic bullae • Purpura ... • Severe Liver Disease ... #treatment #management
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
multiforme-like lesions, palpable ... purpura, Pathergy ... : Arterial (MCC-small ... Syndrome #diagnosis #management ... signs #symptoms #rheumatology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Post Transfusion Purpura ... (PTP): Occurs 7 ... Causes purpura & ... Transfusion #diagnosis #management ... #hematology #reactions