145 results
Localized skin infections and associations: Cellulitis, Bite wounds, Ulcers, Nodules, Eschars 

#SSTIs
#associations
#SkinInfections
#cellulitis
#ulcer
#eschar
#bites
#nodules
#differential
#diagnosis
#infectiousdisease
associations: Cellulitis, Bite ... ulcer #eschar #bites ... #nodules #differential
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Liver Enzymes - Differential ... US - Dilated Bile ... Ducts • Common Bile ... Duct Stone • Biliary ... #LiverEnzymes #Differential
Mechanism of Action of Bile Acid Sequestrants
Bile Acid Sequestrants → ↓ Hepatic Bile Acid Pool →
Mechanism of Action of Bile ... Sequestrants Bile ... Sequestrants → ↓ Hepatic Bile ... Pool → ↑ Hepatic Bile ... Plasma LDL-C #biliary
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
genes coding for bile ... Dysfunction - Biliary ... certain drugs, biliary ... external pressure on bile ... #unconjugated #differential
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary ... of intralobular bile ... No extrahepatic biliary ... ducts Differential ... malignancy #Primary #Biliary
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
ALP) Elevation - Differential ... Drugs - Primary biliary ... PSC - Other biliary ... diseases/Bile duct ... ALP #Elevation #Differential
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Function Tests - Differential ... • US - Normal Bile ... • US - Dilated Bile ... - CBD stone, Biliary
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
hepatitis - Acute biliary ... Hemochromatosis - Primary biliary ... Acute #Causes #Differential
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
Primary Biliary ... gradual loss of bile ... inflammation and biliary ... #PBC #Primary #Biliary
Diseases of the Biliary Tract
Asymptomatic gallstones - Asymptomatic
Symptomatic gallstones - Biliary pain
Cholesterolosis of gallbladder - Usually
Diseases of the Biliary ... Symptomatic gallstones - Biliary ... cholecystitis - Biliary ... Asymptomatic or biliary ... #diseases #differential