110 results
Pseudogout: pathogenesis and clinical findings
 - Idiopathic (vast majority of cases) -> Mechanism unknown
 - Familial
ANKH gene, Incr pyrophosphate ... dihydrate (CPPD ... activity, reduces pyrophosphate ... and/or x-ray - CPPD ... Chondrocalcinosis #Pseudogout #CPPD
Tracheal Descent Sign

Paradoxical inward movement of the trachea during inspiration. Seen in this COPD patient in
Seen in this COPD ... patient in severe respiratory ... Video via Dr. ... Sign #clinical #video ... #physicalexam #respiratory
Campbell’s sign or Tracheal Descent in Longstanding COPD

Patients with longstanding COPD may show downward displacement of
in Longstanding COPD ... with longstanding COPD ... Tracheal #Descent #COPD ... #clinical #video ... physicalexam #pulmonary #respiratory
Hoover’s Sign on Physical Exam

Paradoxical retraction of the lower intercostal spaces on inspiration in this patient
patient in severe COPD ... PhysicalExam #clinical #video ... #pulmonary #COPD ... #respiratory
Hypophosphatemia and Hypoxia - Pathophysiology

↓ Phosphate leads to ↓ red cell 2,3-DPG and a  reduction
Respiratory muscle ... phosphorus is seen in COPD ... It is severe in respiratory ... patients with COPD ... Respiratory muscles
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
CPPD vs Gout ... == CPPD == Think ... About CPPD When ... Pathophysiology: • Pyrophosphate ... Asymptomatic CPPD
Noninvasive Positive Pressure Ventilation (NIPPV)

Expiratory & Inspiratory Positive Airway Pressure
Both increase intrathoracic pressure, which can decrease
In COPD, decreases ... pulmonary edema) • COPD ... patients (ie., CHF or COPD ... • Other acute respiratory ... exacerbation) • Chronic respiratory
Hoover's Sign

Hoover’s sign refers to inward movement of the lower rib cage during inspiration- instead of
associated with COPD ... COPD, and more specifically ... Sign #Pulmonary #COPD ... #PhysicalExam #Video ... #Paradoxical #Respiratory
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD)

Pathophysiology:
Pyrophosphate produced by chondrocytes likely precipitates with calcium to
Summary - Calcium Pyrophosphate ... Pathophysiology: Pyrophosphate ... calcium to form CPP ... Chronic calcium pyrophosphate ... #Calcium #Pyrophosphate
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
nephrocalcinosis • CPPD ... • Inorganic pyrophosphate ... PPi (inorganic pyrophosphate ... Phosphatase: • Respiratory ... : - respiratory