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Red cell autoagglutination is the process whereby red cells clump together forming aggregates. This is seen
red blood cells (RBCs ... serum due to the RBCs ... #Clinical #Path ... #Blood #Smear #Microscopy ... #RBC #Autoagglutination
Red cell autoagglutination is the process whereby red cells clump together forming aggregates. This is seen
red blood cells (RBCs ... serum due to the RBCs ... #Clinical #Path ... #Blood #Smear #Microscopy ... #RBC #Autoagglutination
Red Blood Cell Morphology Atlas

Size variation, Hemoglobin distribution,  
Hypochromia,  
Shape variation,  
Inclusions, 
Red
#Diagnosis #Path ... #Blood #Smear # ... RBC #Morphology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
/ Normochromic RBCs ... on Smear • Chronic ... TIBC, Hypochromic RBCs ... Decreased RBC ... Spherocytes on Smear
A normal peripheral blood smear indicates the appropriate appearance of red blood cells, with a zone
peripheral blood smear ... the size of the RBC ... #Clinical #Path
Here is another peripheral blood smear demonstrating changes with iron deficiency anemia. Note the increased zone
peripheral blood smear ... shapes of the RBC's ... #Clinical #Path
Plasmodium Falciparum Blood Smear.
Key features suggesting Plasmodium falciparum:
- extreme parasitemia
- normocytic RBCs (vivax, ovale prefer big
Falciparum Blood Smear ... parasitemia - normocytic RBCs ... multiples per RBC ... rare in blood smears ... Falciparum #Blood #Smear
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Normal Blood Smear ... Neutrophils - Low RBC ... Pernicious Anemia RBCs ... Cells, Normal WBCs
Peripheral Blood shows a subset of atypical lymphocytes with hairy-like cytoplasmic projection.
#Clinical #Path #BloodSmear #Blood #Smear
#Clinical #Path ... BloodSmear #Blood #Smear
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
2) External (RBC ... 3) Internal (RBC ... Peripheral Blood Smear ... ↑ abnormal RBCs