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diagnosis hematology differential management oncology causes hemolytic leukemia rash workup chronic hemeonc lymphocytic summary agglutinin arthritis bandemia cancer carcinoma cbc
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... Headaches, bone pain, fever ... - infiltrates (anemia ... Lymphadenopathy • HSM • Fevers ... #Leukemia #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... Consider sickle cell ... bartonella (oroya fever ... #workup #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Differential Diagnosis Algorithm ... DAT (-) → Sickle Cell ... malignancy, autoimmune disease ... Recent travel/Fevers ... Differential #Diagnosis #Algorithm
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... cells can indicate disease ... • Neutropenia, anemia ... leukemia #CLL ... workup #oncology #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... • hemolytic anemia ... malignancies -> CLL ... Symptoms: High fevers ... #hematology #diagnosis
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH These rashes can be especially challenging and are associated with devastating differential
in vasculitic diseases ... petechiae/purpura with fever ... require emergent evaluation ... While all patients ... #Diagnosis #Dermatology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... ) B symptoms → fevers ... 5) Symptoms of anemia ... chemotherapy for low-risk disease ... marrow failure with anemia
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Left Shift: • Cell ... • Autoimmune diseases ... tachycardia or fever ... count on initial evaluation ... neutrophil #WBC #CBC #hematology
Evaluation of suspected incomplete Kawasaki Disease 1. AHA consensus recommendations 2. Infants ≤6 months old on day ≥7
Evaluation of suspected ... incomplete Kawasaki Disease ... old on day ≥7 of fever ... Albumin ≤3.0 g/dL, anemia ... within 10 d of fever
Septic Arthritis - Diagnosis and Management Summary Clinical Exam: hot, swollen, pain with passive AND active ROM
active ROM +/- fever ... necrosis, Lyme disease ... culture, Gram stain, cell ... count, and crystal evaluation ... MH/CCF/CWRU EM
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