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hemolytic activation agglutinin algorithm causes cell disease disorders elevated gap globulin hemolysis laboratory ldh macrophage management mas oncology plasmacytoma platelet
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Autoimmune: Warm AIHA, Cold ... Defects, Drugs, Liver ... Defects: Sickle cell anemia ... Dehydrogenase ↑ ... #Diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Agglutination - Cold ... Glucose-6-phosphate dehydrogenase ... #workup #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
anemia • Cold ... Hyperbilirubinemia • Elevated lactate ... dehydrogenase ... younger pts) Differential ... #hematology #diagnosis
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... Dehydrogenase ( ... LDH) - Differential ... Diagnosis Framework ... RBCs, muscle, liver
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... practices that could ... : INR/PT, aPTT(liver ... changes), high MCV anemia ... #Workup #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
result in severe anemia ... elevation Serum lactate ... dehydrogenase ( ... WBC count and differential ... #Workup #Hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
rash) • Heart, lung ... with leukopenia, anemia ... thrombocytopenia • Liver ... Triglycerides • ↑ Lactate ... dehydrogenase
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
common - GI tract, liver ... • No CRAB - no anemia ... lytic lesions • Lactate ... dehydrogenase ( ... #Workup #Hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Sarcoidosis) • Liver ... ovarian tumors, lung ... Gap #ProteinGap #differential ... #diagnosis #hematology
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