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activation cell elevated globulin hemolysis infections infectiousdiseases laboratory ldh macrophage management mas mycobacteria nontuberculous ntm oncology plasmacytoma protein proteingap rheumatology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Defects, Drugs, Liver ... Defects: Sickle cell anemia ... Haptoglobin ↓ - Lactate ... Dehydrogenase ↑ ... #Diagnosis #hematology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... Dehydrogenase ( ... LDH) - Differential ... Diagnosis Framework ... RBCs, muscle, liver
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
result in severe anemia ... elevation Serum lactate ... dehydrogenase ( ... WBC count and differential ... #Workup #Hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
rash) • Heart, lung ... with leukopenia, anemia ... thrombocytopenia • Liver ... Triglycerides • ↑ Lactate ... dehydrogenase
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Hematologic malignancy ... (elevations of liver ... Bone Marrow - Anemia ... Diagnosis Of NTM ... NTM #Infections #differential
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Sarcoidosis) • Liver ... ovarian tumors, lung ... #ProteinGap #differential ... #diagnosis #hematology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
common - GI tract, liver ... • No CRAB - no anemia ... lytic lesions • Lactate ... dehydrogenase ( ... #Workup #Hematology
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