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algorithm differential hematology infectiousdiseases injury hepatitis lfts rheumatology transaminitis 1 accessories aclf aflp aih autoimmune blastomycosis calcium capsulatum causes cdi
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... presentation • Chronic ... #differential #Diagnosis ... #Management #gastroenterology ... #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Injury (DILI) ... #Chronic #Liver ... #gastroenterology ... #management #diagnosis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis ... non-essential drug/HDS treatments ... dechallenge • Acute ... #Injury #Diagnosis ... #Algorithm #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
- Differential Diagnosis ... Cirrhosis • Chronic ... Hepatopathy • Acute ... (>1000): • DILI ... #hepatology #transaminitis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential Diagnosis ... > 2 • NASH, Chronic ... injury: > 3 • Chronic ... #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
ALT AST:ALT Ratios ... > 2 • NASH, Chronic ... injury: > 3 • Chronic ... #chemistry #diagnosis ... #differential #Hepatology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... headache, malaise) → Acute ... 10x ULN), ↑Tbili/Dbili ... ) Differential Diagnosis ... #Pregnancy #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
B - Diagnosis and ... Management Algorithm ... HBV #Algorithm #Diagnosis ... #Management #Treatment ... #Hepatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
subclinical disease to acute ... liver failure ... - Symptoms of chronic ... regarding need for treatment ... #Management #Hepatology
Chronic Pancreatitis Definition: A pathologic fibroinflammatory syndrome of the pancreas in individuals with genetic, environmental, and/or other
Chronic Pancreatitis ... and recurrent acute ... EmoryGastroHep #Chronic ... #management #gastroenterology ... #treatment
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