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management differential hemophagocytic hlh lymphohistiocytosis aids cns hematology hemeonc hiv infectiousdiseases inflammatory iris neurology reconstitution rheumatology summary syndrome treatment
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
- Differential Diagnosis ... cells per μL • Diagnosis ... • Combination antiretroviral ... required until immune ... Demyelinating disease
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Immune Reconstitution ... worsening of that disease ... opportunistic infection ... after initiating antiretroviral ... pericarditis, peritoneal disease
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... that disrupts immune ... • Autoimmune diseases ... Others: Cellular immune
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Triggers: ▪ Infections ... ▪ Autoimmune diseases ... Pathophysiology ... of NK cells and CD8 ... underlying trigger: Infections
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