19 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Cerebrovascular Disease ... thrombosis and/or blood-brain ... #neurology #rheumatology ... #management #treatment
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
suspicion of severe disease ... splenomegaly, abnormal neurology ... , back pain Haematology ... Pathway #Child #Peds ... #Pediatrics #Diagnosis
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... et diutinum Neurologic ... Sneddon-Wilkinson disease ... #Differential #Diagnosis ... #Oncology
Hearing Loss - Differential Diagnosis Framework

Hearing Loss Types:
• Conductive
• Sensorineural
• Mixed
Presbycusis is the most common type
Diagnosis Framework ... include a: • Neurologic ... auditory nerve (CN ... Onset ○ Meniere disease ... ○ HIV ○ Lyme disease
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
on bone marrow leading ... extramedullary disease ... involvement • 30%: CNS ... leukostasis syndrome: CNS ... #Oncology #Diagnosis
The 6 C’s of Primary Sclerosing Cholangitis (PSC)
PSC is a chronic, cholestatic, immune-mediated disease characterized by
The 6 C’s of Primary ... ducts, commonly leading ... asymptomatic at diagnosis ... management. ... #Hepatology
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
life-threatening diseases ... Inflammatory eye disease ... recent DAN) • EMG/NCS ... reveals increasing blood ... #management #treatment
Aortic Dissection Pearls
Aortic dissection is caused by a tear in the tunica intima, the innermost layer
Marfans, EDS ... • Aortic valve disease ... ~60 • Control blood ... Aortic #Dissection #diagnosis ... #management #vascular
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
highly inflammatory disease ... IL-1 and IL-6, leading ... nervous system (CNS ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
membrane into the CNS ... Malnutrition • Wilson's disease ... deficiency • blood ... respiratory failure • Neurologic ... Hyophosphatasia #hepatology