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hematology rheumatology differential activation algorithm alkaline cerebritis child cholangitis classification erythematosus hodgkins hyophosphatasia leukemia limping low lupus lymphoma macrophage mas
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY RED FLAGS - In all cases there are specific markers which
RED FLAGS - In all ... splenomegaly, abnormal neurology ... , back pain Haematology ... Pathway #Child #Peds ... #Pediatrics #Diagnosis
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Cerebrovascular Disease ... thrombosis and/or blood-brain ... #neurology #rheumatology ... #management #treatment
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
on bone marrow leading ... extramedullary disease ... involvement • 30%: CNS ... leukostasis syndrome: CNS ... #Oncology #Diagnosis
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
membrane into the CNS ... Malnutrition • Wilson's disease ... deficiency • blood ... respiratory failure • Neurologic ... Hyophosphatasia #hepatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... et diutinum Neurologic ... Sneddon-Wilkinson disease ... #Differential #Diagnosis ... #Oncology
The 6 C’s of Primary Sclerosing Cholangitis (PSC) PSC is a chronic, cholestatic, immune-mediated disease characterized by
The 6 C’s of Primary ... ducts, commonly leading ... asymptomatic at diagnosis ... management. ... #Hepatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
IL-1 and IL-6, leading ... nervous system (CNS ... tests ↑ AST ↑ ALT ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
work properly, leading ... involve one, two, or all ... Myeloproliferative Disease ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
pulses, bruits, or blood ... asymmetric arm BP readings ... affects the skin, neurologic ... , Elevated AST ALT ... chorioretinitis, CNS
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
accounts for 10% of all ... Workup: • Full Blood ... marrow biopsy - if blood ... number of sites of disease ... #oncology #management
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