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diagnosis management leukemia mds myelodysplastic workup activation aplastic bariatric bypass cell chemotherapy chronic cll complications cyp3a4 differential doac gastric gastroenterology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... cytopenias (usually anemia ... only curative treatment ... Myelodysplastic #Syndrome ... #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... marrow-failure syndromes ... Treatment: ... #oncology #hematology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓) of cytochrome p450 CYP3A4 and P-glycoprotein. DOACs are substrates
interactions) Cancer-treatment ... DOACs thereby leading ... #Chemotherapy #Oncology ... #Hematology #Interactions ... #Table #Pharmacology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
factor (GCSF) treatments ... marrow studies Treatment ... Immunosuppressive treatment ... #diagnosis #hematology ... #oncology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
IL-1 and IL-6, leading ... with leukopenia, anemia ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Neutropenia, anemia ... microglobulin Treatment ... • Richter’s Syndrome ... diagnosis #workup #oncology ... #hematology
Complications after Bariatric Surgery Post Bariatric Intestinal Failure: • Severe protein malnutrition after bariatric surgery • More
Consider refeeding syndrome ... nutrients • TPN for treatment ... deficiencies) Dumping Syndrome ... and prevention ... Gastroenterology and Hepatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
on bone marrow leading ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
the periphery, creating ... • No CRAB - no anemia ... Bone marrow Treatment ... #Plasmacytoma #Oncology ... Diagnosis #Workup #Hematology
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