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diagnosis hematology abnormal algorithm bruising dermatology intravascular management obgyn obstetrics postpartum prolonged pt purpura anemia back bleeding disseminated extravascular hemolysis
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Pre-analytical cause ... Massive hemorrhage ... (DIC) c. ... #diagnosis #differential
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... • Massive hemorrhage ... intravascularcoagulation (DIC ... #diagnosis #differential ... #hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
(DIC) Overview ... Acral cyanosis • Hemorrhagic ... Treat primary cause ... INR < 2.3 - APTT ... #diagnosis #causes
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... Hemorrhage - Differential ... (DIC) • Anti-coagulation ... #PostPartum #Hemorrhage ... #PPH #Differential
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... red to purple, hemorrhagic ... marrow disease - DIC ... Defects: • DIC ... Vasculopathy #Purpura #Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... intravascular coagulation ... (DIC) - HELLP ... Extravascular #Causes ... #differential #
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... inhibitor of a coagulation ... Warfarin • Acute DIC ... discern these causes ... disease • Acute DIC
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Rash - Differential ... than 2 mm) of hemorrhage ... fulminans - DIC ... Complete blood count coagulation
Postpartum Hemorrhage - Differential Diagnosis and Management Uterine Atony (80%) - Most PPH Will respond to
Postpartum Hemorrhage ... - Differential ... epinephrine prn DIC ... fibrinogen, PT/PTT ... #Differential #
Back Pain - Differential Diagnosis Primary Back Pathology: • Musculoligamentous injury (a.k.a. lumbosacral strain) • Spondylosis (i.e.
Back Pain - Differential ... Intervertebral disc ... Retroperitoneal hemorrhage ... #Back #Pain #Differential ... #Diagnosis #causes
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