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differential hepatology rheumatology dermatology generalized management pruritus secondary systemic workup ascites biliary cholangitis disorders glomerulonephritis hemophagocytic hepatomegaly hlh lymphohistiocytosis pbc
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Algorithm Spurious ... Artifact (redo CBC ... Myelogenous Leukemia • Primary ... #Algorithm #Causes
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
- Differential Diagnosis ... Algorithm Malignant ... Biliary Cirrhosis ... #Algorithm #Causes ... #Hepatology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Generalized Differential Diagnosis ... Algorithm - Systemic ... and Primary Causes ... Hyperthyroidism CBC ... #Algorithm #causes
Causes of Ascites - Differential Diagnosis Algorithm Portal Hypertension - Prehepatic: • Portal vein thrombosis • Splenic
Causes of Ascites ... Algorithm Portal ... - Hepatic: • Cirrhosis ... #Algorithm #Hepatology ... #causes
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... decreased PLT count: CBC ... unclear, or if a primary ... Refractory ITP, ... #hematology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... Cirrhosis (PBC) ... 65 years PBC Pathophysiology ... intralobular bile ducts causes ... #workup #hepatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
RPGN has three primary ... pathophysiologic ... causes differentiated ... #differential #diagnosis ... #algorithm #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... assessment+++ Primary ... Drugs, Unknown cause ... treatment #summary #rheumatology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary ... Algorithm Blood ... Hyperthyroidism CBC ... #generalized #dermatology ... #Algorithm #causes
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Vaginal dryness • Primary ... Hypocomplementemia • Can cause ... /aggregate) of CD4 ... biliary cirrhosis ... Nephrogenic DI Hematologic
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