315 results
Addictions: Pathogenesis

Mesolimbic Dopaminergic Pathway:
 • Dopaminergic neurons in Ventral Tegmental Area (VTA) in midbrain under continuous
Addictions: Pathogenesis ... drugs), the VTA releases ... behaviours -> Addiction ... Tolerance and Withdrawal ... ) #Drug #Addiction
Alcohol Use Disorder - Maintenance Treatment
Naltrexone (first line) - First line for most people without contraindications
anxious, EtOH withdrawal ... abstaining, prevents relapse ... abstaining, prevents relapse ... pharmacology #table #addiction
Opioid Use Disorder Medications - Pharmacokinetics

Buprenorphine is a partial mu-opioid receptor agonist with low intrinsic activity,
suppressing opioid withdrawal ... modulating opioid withdrawal ... in modulating relapse ... stages of the addiction ... action prevents withdrawal
ED-Bridge Buprenorphine Algorithm for management of acute opiate withdrawal in the ED

#Management #Opioid #Withdrawal #Emergency #Buprenorphine
of acute opiate withdrawal ... Management #Opioid #Withdrawal ... Treatment #Algorithm #Addiction
Comparison of Opioid Withdrawal Profiles

#Opioid #Withdrawal #Pharmacology #Diagnosis #Addiction #Halflife #Timeline #Windows
Comparison of Opioid Withdrawal ... Profiles #Opioid #Withdrawal ... Pharmacology #Diagnosis #Addiction
Opioid Withdrawal Symptom Timeline
Stage l: Up to 8 hours 
Stage II: 8—24 hours 
Stage Ill: Up
Opioid Withdrawal ... days #Opioid #Withdrawal ... #Progression #Addiction
COWS Clinical Opiate Withdrawal Scale
Score: 
5-12 mild; 13-24 moderate; 25-36 moderately severe; more than 36 =
Clinical Opiate Withdrawal ... than 36 = severe withdrawal ... #Diagnosis #Addiction ... #COWS #Opiate #Withdrawal
Buprenorphine Induction Algorithm

#Management #Pain #Withdrawal #Buprenorphine #Induction #Algorithm #Addiction #Prescribing
Management #Pain #Withdrawal ... Induction #Algorithm #Addiction
ZSFG Inpatient Management of Opioid Use Disorder: Buprenorphine
#Management #Addiction #Buprenorphine #Inpatient #Opioid #Withdrawal #COWS #Algorithm
#Management #Addiction ... Inpatient #Opioid #Withdrawal
Treatment of giant cell arteritis (GCA)

1st Line Strategy - GC 0.7 mg/kg/day, except for:
 • Aortitis
necrosis, stroke) Relapses ... • 1st relapse: Incr ... mg/jd • 2nd relapse ... vice-versa • >2 relapses ... Treatment #Management #Relapses