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Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... Lysis Syndrome: • Pathophysiology ... Avoid calcium repletion
Hypophosphatemia and Hypoxia - Pathophysiology ↓ Phosphate leads to ↓ red cell 2,3-DPG and a reduction
and Hypoxia - Pathophysiology ... after phosphate repletion ... Phosphate is a cause ... with phosphate repletion ... respiratory #hypoxia #pathophysiology
Potassium Electrolyte Repletion If patient also has hypomagnesemia, replete magnesium before repleting potassium Oral: • Pills (ask pharmacy
Potassium Electrolyte Repletion ... magnesium before repleting ... Intravenous (can cause ... #Electrolyte #Repletion
Magnesium Electrolyte Repletion Oral - Only do if patient does not tolerate IV • Magnesium oxide (can
Magnesium Electrolyte Repletion ... Magnesium oxide (can cause ... diarrhea and cause ... complex (does not cause ... #Electrolyte #Repletion
Causes of Metabolic Alkalosis - Differential Diagnosis Algorithm Urine chloride < 20 mmol/l - Chloride responsive (Chloride
Causes of Metabolic ... responsive (Chloride depletion ... use, Severe K depletion ... Metabolic #Alkalosis #Causes
Electrolyte Repletion Significant electrolyte depletion can result in serious complications. These guidelines are meant to assist with
Electrolyte Repletion ... Significant electrolyte depletion ... mechanisms can all cause ... the underlying cause ... essential for repletion
Jaundice - Pathophysiology and Causes - Amy Chung, MD, MSc @AmyChung #Jaundice #Pathophysiology #Differential #Unconjugated #Causes #Diagnosis
Jaundice - Pathophysiology ... and Causes - ... #Jaundice #Pathophysiology ... #Unconjugated #Causes
Intern Pocket Cards - Electrolyte Repletion Guide Electrolyte Repletion: - Potassium (ref range 3.5-4.5) - Magnesium (ref
- Electrolyte Repletion ... Guide Electrolyte Repletion ... #Electrolyte #Repletion
Hypophosphatemia - Differential Diagnosis Algorithm • Decreased intake/absorption: Starvation, Alcoholism, Malabsorption, Phosphate binder use • Redistribution/
Acute- without depletion ... - Acute- with depletion ... Diagnosis #Algorithm #causes
Causes of Metabolic Alkalosis - Differential Diagnosis Chloride depletion syndromes • Gastrointestinal losses -
Causes of Metabolic ... Diagnosis Chloride depletion ... administration Other causes ... Severe potassium depletion ... Differential #Diagnosis #Causes
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