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Antiarrhythmics Pharmacology Summary Cardiac Conduction Phases: Phase 0 - Ventricular Depolarization: • Na+ channels open leading to a
Classification: CLASS ... duration - CLASS ... duration - CLASS ... & AP duration CLASS ... ) CLASS 4 - Calcium
Action potential in cardiomyocytes The action potential in typical cardiomyocytes is composed of 5 phases (0-4), beginning
phase Phase 0: Depolarization ... Phase 1: Early repolarization ... phase Phase 3: Repolarization ... Myocytes #Phases #Depolarization ... #Repolarization
Antiarrhythmics - Vaughan Williams Classification: CLASS 1 - Sodium Channel Blockers: • MOA: Block fast Na+ channels
Classification: CLASS ... and magnitude of depolarization ... prolong AV node repolarization ... interval (delays time repolarization ... prolong AV node repolarization
Class I Antiarrhythmics and their Key Pharmacologic Properties Class IA = Quinidine, Procainamide, Disopyramide ("Quarter PounDer") Class IB
Class I Antiarrhythmics ... Properties Class ... Mayo, Pickle") Class ... involved in phase 3 repolarization ... • Prolongs repolarization
Antiarrhythmics - Vaughan Williams Classification Class I (Ia, Ib, Ic) - Na+ Channel Blockade • Slows depolarization
Classification Class ... Blockade • Slows depolarization ... Widens QRS complex Class ... Blockade • Slows depolarization ... Blockade • Slows depolarization
Action Potential: Depolarization and repolarization of a neuron #ActionPotential #Depolarization #Repolarization #Neuron #Neurology #Pathophysiology
Action Potential: Depolarization ... and repolarization ... ActionPotential #Depolarization ... #Repolarization
Major electrocardiogram findings induced by left ventricular hypertrophy (LVH) An increase in left ventricular mass augments the
alteration in repolarization ... in left atrial depolarization
Differential Diagnosis for ST Segment Elevations - ACUTE STEMI - PULMONARY EMBOLISM - LBBB
Differential Diagnosis ... - BENIGN EARLY REPOLARIZATION ... STElevation #STEMI #Differential
Hyperkalemia shortens repolarization; changes in the T wave provide the earliest clues to hyperpotassemia. - At
Hyperkalemia shortens repolarization ... 6.0 mEq/L, rapid repolarization ... causes peaked T ... in conduction causes ... wave to produce classic
Drugs Causing Acute Pancreatitis Class Ia: The medications in which there was a rechallenge and other causes
Pancreatitis Class ... Class lb: Atleast ... Class II: Cases ... #Differential # ... #Medications #Classes
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