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diagnosis differential vasculitis ana antibodies antibody antineutrophil antinuclear antinxp2 antinxp2dm autoimmune classification dermatology diseases erythematosus lupus management myopathy myositis sle
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antibody) and ANCA ... Polymyositis and dermatomyositis ... polyangiitis without renal ... + 30-60% • Renal-limited ... antibodies #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pulmonary and renal ... Associated - ANCA ... purpura: strong sign ... • Urinalysis (Renal ... differential #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
pulmonary and renal ... purpura: Strong sign ... Pauci Immune (ANCA ... No Granulomas (ANCA ... Differential #Diagnosis #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Diagnosis: • ANCA-associated ... Still disease, dermatomyositis ... Non-autoimmune rheumatologic ... APLA/LAC: • Renal ... Erythematosus #Diagnosis #Rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
Anti-NXP-2 Dermatomyositis ... chest (in a V-sign ... shoulders (in a shawl sign ... • Clear cell renal ... diagnosis #management #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... • Anti-NXP2 (ANA ... papules and Gottron sign ... ) • Shawl sign ... Myositis #Myopathy #rheumatology
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