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diagnosis differential ana antibody antineutrophil antinuclear antinxp2 autoimmune classification dermatology diseases erythematosus lupus management myopathy myositis sle systemic vasculitides vasculitis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... Polymyositis and dermatomyositis ... polyangiitis without renal ... + 30-60% • Renal-limited ... #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pulmonary and renal ... purpura: strong sign ... ) pattern: antibodies ... • Urinalysis (Renal ... differential #diagnosis #rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
• Antibodies targeting ... chest (in a V-sign ... • Clear cell renal ... #AntiNXP2 #Dermatomyositis ... diagnosis #management #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Diagnosis: • ANCA-associated ... Still disease, dermatomyositis ... Non-autoimmune rheumatologic ... APLA/LAC: • Renal ... 1, SCL-70, RNP antibodies
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... • Anti-NXP2 (ANA ... papules and Gottron sign ... ) • Shawl sign ... Myositis #Myopathy #rheumatology
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