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brain causes clinical crypto cryptococcal differential hematology hemophagocytic hlh icl idiopathic lymphocytopenia lymphohistiocytosis lymphopenia management meningitis mri radiology rheumatology summary
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
(ICL) / Lymphocytopenia ... DIAGNOSTIC ... CRITERIA FOR ICL ... EBV. CMV. ... #Lymphopenia #ICL
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... Infections+++: Virus (EBV ... biologics (CMV +++, EBV ... of emergency, ICU ... #management #treatment
Cryptococcal meningitis on T2 MRI 30 M from sub-Saharan Africa presents w/ progressive Headache x1 mo, +neck
immunocompromised CD4 ... Standard treatment ... survival by 25% ↑ ICP ... to normalize ICP ... approximately 15% ↑ in rate
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