3 results
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Creatine Kinase ... (COVID19, CMV/EBV ... Illness Myopathy (ICU ... infarction, Acute renal injury ... differential #diagnosis
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Coxsackie, CMV, EBV ... diseases (mevalonate kinase ... Muscular: normal CK ... #management #treatment ... #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Infections+++: Virus (EBV ... +, Adult-onset Still ... biologics (CMV +++, EBV ... of emergency, ICU ... #management #treatment