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differential agglutinin aids anemia betadglucan biomarkers causes cns cold comparison disease fungal galactomannan hemolytic hemophagocytic hiv hlh icl idiopathic infections
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
(ICL) / Lymphocytopenia ... DIAGNOSTIC ... CRITERIA FOR ICL ... EBV. CMV. ... #diagnosis #hematology
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
- Other positives ... infection (IFI) in hematologic ... cut-offs defined in clinical ... - Frozen ice-pops ... Galactomannan #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... accumulation of clinical ... Assessment • Clinical ... biologics (CMV +++, EBV ... of emergency, ICU
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
- Differential Diagnosis ... cells per μL • Diagnosis ... should be based on clinical ... effect/Edema • EBV ... and <25% culture positive
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral Infection Clinical ... dehydrogenase • Positive ... hemolysis • C3↓ C4 ... - Mycoplasma, EBV ... hemolytic #anemia #hematology
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