10 results
TTH48 - Targeted Temperature Management for 48 vs 24 Hours and Neurologic Outcome After Out-of-Hospital Cardiac
- A Randomized Clinical ... admitted to the ICU ... #TTM48 #TTH48 #CriticalCare ... #ICU #VisualAbstract ... #EBM
POLAR Randomized Clinical Trial - Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients
POLAR Randomized Clinical ... Hypothermia on Neurologic ... Hypothermia #TBI #CriticalCare ... #ICU #VisualAbstract ... #EBM
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... +++: Virus (EBV, ... biologics (CMV +++, EBV ... of emergency, ICU
Sepsis - Diagnosis and Management
Life-threatening organ dysfunction caused by a dysregulated host response to infection
SEPTIC SHOCK
host response to infection ... Clinical construct ... likelihood of prolonged ICU ... #QSOFA #SIRS #criticalcare ... #icu
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan
Beta-D-Glucan:
 • Polysaccharide cell wall component of many fungi
 • Pathogens:
invasive fungal infection ... (IFI) in hematologic ... cut-offs defined in clinical ... - Frozen ice-pops ... Galactomannan #diagnosis
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Clinical Presentation ... dehydrogenase • Positive ... - Mycoplasma, EBV ... hemolytic #anemia #hematology ... #diagnosis
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia 

DIAGNOSTIC CRITERIA FOR ICL
 • Persistent CD4 T-cell lymphopenia
 •
CD4 Lymphopenia (ICL ... Lymphocytopenia DIAGNOSTIC ... myelodysplasia) • Infections ... EBV. CMV. ... #diagnosis #hematology
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
- Differential Diagnosis ... cells per μL • Diagnosis ... should be based on clinical ... effect/Edema • EBV ... and <25% culture positive
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework

Viral Encephalitis:
MCC: Enteroviruses (e.g., coxsackievirus
CNS Infections - ... virus • CMV • EBV ... • Common clinical ... • Gram stain: Positive ... #neurology #meningitis
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• History of EBV ... infection • Family ... Hodgkin Lymphoma - Clinical ... and usually CD15 positive ... classification #hematology