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diagnosis galactomannan management aids aspergillus autoimmune biomarkers comparison differentiation falsepositives gout hematology hiv infectiousdiseases laboratory lung myopathy myositis oncology pulmonary
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome in APML ... Attempt if high risk ... Subacute-Acute: • Common: fever ... initiation • Differential ... Diagnosis: Infection
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
infection (IFI) ... surfaces - Infections ... useful in high risk ... BAL GM does not differentiate ... #Biomarkers #BetaDGlucan
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
surfaces, Albumin, Infections ... useful in high risk ... in BAL does not differentiate ... post-2010 almost never ... blood products #BetaDGlucan
Lung Infections in HIV - Differential Diagnosis Framework Disease by CD4 Count: Any CD4 Count: • Mycobacterium tuberculosis,
Lung Infections ... in HIV - Differential ... Pseudomonas FUNGAL ... • CT: Halo sign ... Pneumonia: • Risk
Gout - Diagnosis and Management Summary 3 Conditions for Gout to Manifest: 1. Hyperuricemia 2. Monosodium urate deposition in
inflammatory response Risk ... forefoot, ankles, knees ... 12-24 Hours • Fever ... Diagnose concomitant infection ... drug failure • Risk
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
disease Malignancy Risk ... and increased risk ... dermatomyositis) Malignancy Risk ... and increased risk ... and increased risk
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