12 results
Fever Patterns - Differential Diagnosis Framework

Continuous Fever:
Temp > 38°C with only 1 degree fluctuation in 24
Differential Diagnosis ... : Temperature rises ... Brucellosis Faget's Sign ... For every 1°F rise ... #Patterns #Differential
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan
Beta-D-Glucan:
 • Polysaccharide cell wall component of many fungi
 • Pathogens:
invasive fungal infection ... surfaces - Infections ... useful in high risk ... BAL GM does not differentiate ... Fungal #Biomarkers #BetaDGlucan
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives
1,3-Beta-D-Glucan
 • Cell wall component of many fungi
surfaces, Albumin, Infections ... useful in high risk ... in BAL does not differentiate ... post-2010 almost never ... blood products #BetaDGlucan
Pediatrics Sepsis Screening
SIGNS OF INFECTION?
 • Fever (>38C)
 • Hypothermia (<36C)
 • Cough/chest pain/respiratory distress
 •
Pediatrics Sepsis ... OF INFECTION? ... • Fever (>38C) ... RISK MEDICAL CONDITIONS ... • Other high-risk
Lung Infections in HIV - Differential Diagnosis Framework

Disease by CD4 Count:
Any CD4 Count:
 • Mycobacterium tuberculosis,
Lung Infections ... in HIV - Differential ... since cART) Aspergillus ... • CT: Halo sign ... Pneumonia: • Risk
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
pulmonary symptoms • Rheumatologic ... MUCORMYCOSIS • Risk ... • Cough, fever ... Encapsulated yeast • At risk ... ASPERGILLOSIS • Aspergillus
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Attempt if high risk ... Subacute-Acute: • Common: fever ... initiation • Differential ... Diagnosis: Infection ... diagnosis #management #hematology
Gout - Diagnosis and Management Summary

3 Conditions for Gout to Manifest:
1. Hyperuricemia
2. Monosodium urate deposition in
inflammatory response Risk ... forefoot, ankles, knees ... 12-24 Hours • Fever ... Diagnose concomitant infection ... drug failure • Risk
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
diagnose concomitant infection ... inflammatory response Risk ... forefoot, ankles, knees ... 12-24 Hours • Fever ... Gout #Comparison #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... permanent alopecia Differential ... fibromyalgia) • Infections ... to: Arthritis, Fever ... Thrombosis highest risk