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diagnosis comparison erythematosus fungal galactomannan lupus vasculitis arthritis aspergillus autoimmune biomarkers classification clues cppd falsepositives joint laboratory management monoarthritis monoarticular
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Pain - Arthritis Differential ... noninflammatory Signs ... • Rheumatic fever ... • Lyme • Gout ... arthritis • SLE
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
the face (many differential ... 9) Unexplained fever ... , when infection ... including in children (pediatric ... erythematosus #rheumatology
Gout - Diagnosis and Management Summary 3 Conditions for Gout to Manifest: 1. Hyperuricemia 2. Monosodium urate deposition in
inflammatory response Risk ... forefoot, ankles, knees ... 12-24 Hours • Fever ... Diagnose concomitant infection ... drug failure • Risk
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
diagnose concomitant infection ... inflammatory response Risk ... forefoot, ankles, knees ... 12-24 Hours • Fever ... #Comparison #rheumatology
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
invasive fungal infection ... useful in high risk ... BAL GM does not differentiate ... or GVHD (leaky gut ... Fungal #Biomarkers #BetaDGlucan
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... permanent alopecia Differential ... fibromyalgia) • Infections ... to: Arthritis, Fever ... Thrombosis highest risk
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
surfaces, Albumin, Infections ... useful in high risk ... in BAL does not differentiate ... or GVHD (leaky gut ... blood products #BetaDGlucan
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... diseases, such as SLE ... purpura: Strong sign ... purpura, joint & gut ... #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
to exclude are infections ... Vasculitis: • Fevers ... purpura: strong sign ... vasculitis, and SLE ... #diagnosis #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
disease Malignancy Risk ... and increased risk ... dermatomyositis) Malignancy Risk ... and increased risk ... and increased risk
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