13 results
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
dosing and bridging ... #DOAC #Bridging ... Anticoagulant #Anticoagulation ... #Dabigatran #Apixaban ... #Rivaroxaban #Edoxaban
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
Anticoagulants Common ... Reversal Agents - Warfarin ... (Praxbind) - Apixaban ... Betrixaban (Bevyxxa), Edoxaban ... (Lixiana), Rivaroxaban
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
Clearance of Oral Anticoagulant ... Agents Warfarin ... Hepatic, 0% Renal Apixaban ... Hepatic, 80% Renal Edoxaban ... Hepatic, 50% Renal Rivaroxaban
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
DOAC: Cheat Sheet ... : Apixaban (25% ... @Bloodman #DOAC ... OralAnticoagulant #Anticoagulation ... #Edoxaban #NOAC
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
Currently, edoxaban ... and rivaroxaban ... for appropriate dosing ... #DOAC #VTE #Malignancy ... Cancer #Algorithm #Anticoagulation
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
Pathophysiology Anticoagulation ... the mainstay of VTE ... (e.g. warfarin) ... accelerates the bridging ... #Dabigatran #Apixaban
Warfarin to DOAC and DOAC to Warfarin Transitions 

Here are a couple of charts to help
Warfarin to DOAC ... and DOAC to Warfarin ... Quick tip: apixaban ... Rivaroxaban is < ... Edoxaban is <2.5
Effect of Anticoagulants on Coagulation Tests
PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Clotting Time Warfarin ... Fondaparinux Rivaroxaban ... Apixaban, Edoxaban ... #Tests #Anticoagulation ... #Testing #Diagnosis
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
patients on chronic anticoagulation ... For patients on warfarin ... clearance (calculated using ... inhibitor) • Apixaban ... , Edoxaban, Rivaroxaban
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
clot #PT #PTT #diagnosis ... #anticoagulant ... #Warfarin #Dabigatran ... thrombin #inhibitor #Apixaban ... #Rivaroxaban #Edoxaban