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diagnosis hematology causes chronic cll lymphocytic agglutinin autoimmune bruising classification cold dehydrogenase elevated erythematosus extravascular hemeonc hemolysis hodgkins intravascular laboratory
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... Table Warm AIHA ... Cold Agglutinin Disease ... #Anemia #AIHA #
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... - Autoimmune (AIHA ... - Autoimmune (AIHA ... lymphoproliferative disorders ... Extravascular #Causes #differential
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
in adults • Disorder ... 5) Symptoms of anemia ... chemotherapy for low-risk disease ... #oncology #hematology ... hemeonc #diagnosis #management
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
women • 15% of AIHA ... • Symptoms of anemia ... anemia • Cold ... younger pts) Differential ... #hemolytic #anemia
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cells can indicate disease ... lymphoproliferative disorders ... • Neutropenia, anemia ... thrombocytopenia • AIHA ... diagnosis #workup #oncology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... anemia, PNH, immune ... paralyses CNS Disorders ... Lymphomas • Leukemias ... Dehydrogenase #Elevated #differential
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Coagulopathy) SMZL: • AIHA ... • Coombs (-) hemolytic ... anemia due to cold ... Hematology #Monoclonal #Differential ... #Diagnosis #Oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... ) • Endocrine disorders ... Hematologic: • AIHA ... lymphopenia, low PLT • Anemia ... Hodgkin lymphoma and leukemia
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... • Hairy Cell Leukemia ... Myeloproliferative Disease ... blood count with differential ... diagnosis #hematology #oncology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Non-immune - Haemolytic ... Congenital heart disease ... infiltration (e.g. leukaemia ... bypass Vascular disorders ... pediatrics #diagnosis #differential
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