28 results
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Causes of Anemia ... - Differential Diagnosis ... Serum B12 - Anti-IF ... Serum B12 - Anti-IF ... #Hematology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
late adulthood • Diagnosis ... : • Low serum IgG ... 300 mg/dL) • Low ... explanation for the low ... DDX - Other causes
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... staining): • Low ... #differential #diagnosis ... #algorithm #rheumatology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... Malnutrition • Wilson's disease ... collection with EDTA Pathophysiology ... Phosphatase: • Other causes ... • Elevation of serum
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
protease activity - A low ... hallmark for the disease ... If the value is low ... Mild-to-moderate elevation Serum ... #Workup #Hematology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... • Autoimmune diseases ... factor level • Low ... classification #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Cerebrovascular Disease ... , PRES Pathophysiology ... autoantibodies that will cause ... #rheumatology # ... cerebritis #diagnosis
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
Spot PC (protein ... in monitoring low-level ... infections are common causes ... testing #workup #diagnosis ... nephrotic #nephritic #nephrology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... contents into serum ... , Elevated Cr, Low ... Syndrome #TLS #diagnosis
Abnormalities in Rate and Rhythm of Breathing 
Normal 
The respiratory rate is about 14—20 per min
restrictive lung disease ... , and stop for short ... Breathing In lung disease ... Abnormalities #Abnormal #Diagnosis ... #PhysicalExam