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differential rheumatology rash algorithm clinical palpable physicalexam cryoglobulins cutaneous dermatologic dermpath glomerulonephritis granulomatosis hematology hsp iga joint lesions manifestations nonpalpable
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... IgA nephropathy, Henoch-SchonIein ... Purpura Anti-GBM ... Glomerulonephritis #Vasculitis ... #differential #diagnosis
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... • Pauci-immune vasculitis ... : Vasculitis: ... • Henoch-Schönlein ... Granulomatous vasculitis
Palpable Purpura seen in Henoch Schonlein Purpura (HSP, IgA Vasculitis) 55 year old male on tuberculosis treatment
Schonlein Purpura ... (HSP, IgA Vasculitis ... #Henoch #Schonlein ... #HSP #IgA #Vasculitis ... #dermatology #skin
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Hypersensitivity vasculitis ... • Henoch Schönlein ... purpura • PAN ... Antiphospholipid-antibody syndrome • Vasculitis ... #joint #pain #skin
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
often present • Henoch ... Schonlein Purpura ... tract, and often causes ... Vasculitis - Skin ... #rheumatology #classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• IgA vasculitis ... (Henoch-Schönlein ... small-vessel vasculitis ... • Vasculitis ... #rheumatology #vasculitis
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
: Vasculitis: ... Leukocytoclastic vasculitis ... • Ig A vasculitis ... associated small vessel vasculitis ... HCV, HBV Not Vasculitis
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
correlations • Purpura ... Identification of causes ... (5%): PAN > GPA ... #dermpath #dermatology ... signs #lesions #diagnosis
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Infection - Vasculitis ... lesions • Severe pain ... Schonlein Purpura ... - Autoimmune Vasculitis ... cryoglobulins • Skin
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
MPO > PR3 60/ GPA ... often present) Henoch ... Schonlein Purpura ... tract, and often causes ... / ANCA + MPO) Cryoglobulinemic
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