11 results
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
• Petechiae, Palpable ... • Henoch-Schönlein ... cryoglobulinemia ... #dermatology #rash ... #diagnosis #rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
Vessel: Petechiae, Palpable ... purpura, Hemorrhagic ... - GPA Cutaneous ... #Vasculitis #skin ... #dermatology #rheumatology
Palpable Purpura seen in Henoch Schonlein Purpura (HSP, IgA Vasculitis)

55 year old male on tuberculosis treatment
Schonlein Purpura ... (HSP, IgA Vasculitis ... #Purpura #Henoch ... #IgA #Vasculitis ... #dermatology #skin
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Lupus Nephritis, Cryoglobulinemia ... Normal Complement: IgA ... nephropathy, Henoch-SchonIein ... Purpura Anti-GBM ... #rheumatology
Henoch Schonlein Leg Rash - Palpable Purpura
Purpura: Low Platelets or Vasculitis?
45 years old, seen in our
Henoch Schonlein ... Palpable = vasculitis ... suggestive of Henoch-Schonlein ... purpura (IgA), ... #dermatology #HSP
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Ig A vasculitis ... - GPA - EGPA ... Differential #Diagnosis #hematology ... #rheumatology # ... #dermatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- GPA, EGPA, microscopic ... • IgA vasculitis ... (Henoch-Schönlein ... purpura) • Cutaneous ... classification #rheumatology
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Crohn's disease Palpable ... Henoch Schönlein ... Sarcoidosis • GPA ... Sarcoidosis #dermatology ... differential #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Schonlein Purpura ... (IgA Vasculitis ... skin) • Palpable ... ) • Palpable purpura ... Differential #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often present • Henoch ... Schonlein Purpura ... (IgA vasculitis ... Vasculitis - Skin ... differential #diagnosis #rheumatology