11 results
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Maculopapular rash ... • Henoch-Schönlein ... cryoglobulinemia ... #dermatology #rash ... #diagnosis #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Normal Complement: IgA ... nephropathy, Henoch-SchonIein ... Purpura Anti-GBM ... #differential #diagnosis ... #algorithm #rheumatology
Palpable Purpura seen in Henoch Schonlein Purpura (HSP, IgA Vasculitis)

55 year old male on tuberculosis treatment
Schonlein Purpura ... (HSP, IgA Vasculitis ... #Henoch #Schonlein ... #HSP #IgA #Vasculitis ... #dermatology #skin
Henoch Schonlein Leg Rash - Palpable Purpura
Purpura: Low Platelets or Vasculitis?
45 years old, seen in our
Henoch Schonlein ... suggestive of Henoch-Schonlein ... purpura (IgA), ... #Schonlein #Purpura ... #photo #dermatology
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
Diagnosis Framework ... Petechiae, Palpable purpura ... Urticarial/LCV) - Cryoglobulinemic ... #skin #dermatology ... #rheumatology #
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Henoch Schönlein ... Sarcoidosis • GPA ... Sarcoidosis #dermatology ... #differential #diagnosis ... #rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Skin ulcers ... - GPA, EGPA, microscopic ... • IgA vasculitis ... (Henoch-Schönlein ... classification #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Schonlein Purpura ... (IgA vasculitis ... Vasculitis - Skin ... mucositis - Rash ... #rheumatology #
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... • Ig A vasculitis ... /HSP • Cryoglobulinemia ... - GPA - EGPA ... #hematology #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
, mucositis • Rash ... MPO > PR3 60/ GPA ... Schonlein Purpura ... (IgA Vasculitis ... #Rheumatology