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differential hematology oncology table management vasculitis anemia antinxp2 antinxp2dm aplastic classification cold compared dermatologic dermatomyositis disorders eosinophilia erythemas gpa granulomatosis
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Testing Algorithm ... glucocorticoid treatment ... symptoms (eg, skin ... #Differential #diagnosis ... #hematology #eosinophilia
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
lesions - Wheals ... histology - Mast cell ... neutrophils and eosinophils ... #diagnosis #rheumatology ... #comparison #table
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
gangrenosum) • Urticaria ... Differential Diagnosis ... syndrome • Giant cell ... #rash #diagnosis ... #rheumatology
Scleroderma Like Conditions - Differential Diagnosis Eosinophilic Fasciitis: - Orange peel induration (peau d'orange) of proximal extremities
- Differential Diagnosis ... the mainstay of treatment ... lesions, or localized ... #comparison #table ... #dermatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... CRP GCA (Giant Cell ... progressive) EGPA (Eosinophilic ... Polyangiitis): • Eosinophilia ... #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... lesions • Mononeuritis ... • EGPA: - Eosinophilia ... episcleritis as well ... #rheumatology #
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Headaches • Pale skin ... : - Genetic lesions ... - Hepatitis, eosinophilic ... Anemia #oncology #hematology ... #diagnosis #management
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... normo-complementemic urticarial ... Episodic angioedema+eosinophilia ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Erythemas Summarized Erythema ab igne • A dermatosis that results from repeated exposure to heat (fires, heating
classic targetoid lesions ... shows numerous eosinophils ... PrathitKulkarni #Erythemas #comparison ... #differential #diagnosis ... #dermatology #compared
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
outside bone in soft ... Diagnosis? ... EMD myeloma Diagnostic ... Bone marrow Treatment ... #Workup #Hematology
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