302 results
Selected Clinical Trials of SGLT2 inhibitors in CVD and CKD
EMPA-REG OUTCOME - Empagliflozin lowered CV events
Clinical Trials of SGLT2 ... ASCVD; signal for SGLT2i ... risk; signal for SGLT2i ... outcomes trial in SGLT2i ... mcclaffertyMD #SGLT2
Patient factors influencing the selection Of glucose-lowering drugs Other than SGLT2i and metformin in T2D and
drugs Other than SGLT2i ... metformin in T2D and CKD ... receptor agonist SGLT2i ... , #KDIGO2020 #CKD ... Management in CKD
Chronic Kidney Disease (CKD):

Individualize BP-lowering therapy and treatment targets in people with frailty, high risk of
Kidney Disease (CKD ... progression of CKD ... include RASiand SGLT2i ... heart failure, SGLT2i ... both RASI and SGLT2i
Diabetes Medications Summary Table
Insulin
Lifestyle modifications
Metformin
Sulfonylureas
GLP-1 receptor agonists - ↓ major adverse CV events
TZDs
DPP-4 inhibitors
SGLT2 inhibitors -
-4 inhibitors SGLT2 ... Improved outcomes in CKD
Guideline-Directed Medical Therapy (GDMT) in HFrEF and CKD

 • Class I pillars of HFrEF GDMT across
) in HFrEF and CKD ... diuretics, MRA, SGLT2i ... Therapy #GDMT #CKD
SGLT2 Inhibitors and Cardiovascular Pathophysiology

#SGLT2i #Inhibitors #Cardiovascular #Pathophysiology
SGLT2 Inhibitors ... Pathophysiology #SGLT2i
Definitions of AKI, CKD, AKD
Acute Kidney Injury (AKI):
 • Increase in SCr by 2 50% within
Definitions of AKI, CKD ... , AKD Acute Kidney ... Kidney Disease (CKD ... /CKD • No structural ... damage #AKI #CKD
Cardiovascular and renal effects comparison between SGLT-2 inhibitors
 - Canagliflozin (Invokana)
 - Dapagliflozin (Farxiga)
 - Empagliflozin
comparison between SGLT ... cardiovascular #renal #SGLT2i
SGLT2 Inhibitors and Euglycemic DKA

Risk factors for euglycemic DKA in those on an SGLT2i include:
 •
SGLT2 Inhibitors ... in those on an SGLT2i ... is closed • SGLT2 ... Kat_Watson #SGLT2
How SGLT2 inhibitors block glucose reabsorption in proximal tubule and improve systemic glucose homeostasis:
https://www.ajkd.org/article/S0272-6386(18)30633-4/fulltext

#Pathophysiology #Mechanism #Nephrology
How SGLT2 inhibitors ... Mechanism #Nephrology #SLGT2