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SGLT2 Inhibitors and Euglycemic DKA

Risk factors for euglycemic DKA in those on an SGLT2i include:
 •
SGLT2 Inhibitors ... and Euglycemic DKA ... for euglycemic DKA ... alcohol consumption Diagnostic ... #Euglycemic #DKA
Pathophysiology Euglycemic DKA - Mechanism of SGLT-2 Inhibitors #Pathophys #Endocrine #Euglycemic #DKA #SGLT2 #Mechanism
Pathophysiology Euglycemic DKA ... Endocrine #Euglycemic #DKA ... #SGLT2 #Mechanism
Ketosis Disorders - Comparison Table
 • Starvation Ketosis
 • Alcoholic Ketoacidosis (AKA)
 • Diabetic Ketoacidosis (DKA)
Ketoacidosis (AKA ... Ketoacidosis (DKA ... • Euglycemic DKA ... State (HHS) • DKA ... #differential #diagnosis
Stepwise Approach to Prescription of SGLT2 inhibitors 

Anticipatory Guidance 
• Consider diuretic dose reduction 
Patient Counseling
Prescription of SGLT2 ... • Symptoms Of DKA ... endocrinologists #SGLT2
Metabolic Acidosis with Anion Gap - KILU Mnemonic

K - Ketoacidosis
	• DKA
		- With normal glucose, ask if
Ketoacidosis • DKA ... glucose, ask if on SGLT2 ... ketoacidosis in SGLT2 ... inhibitors and SGLT2 ... Metabolic #Acidosis #diagnosis
DKA DIAGNOSTIC CRITERIA:
1. Serum glucose >250 mg/dL
2. Arterial pH <7.3
3. Serum bicarbonate <18 mEq/L
4. At least
DKA DIAGNOSTIC CRITERIA ... 10% to 30% of DKA ... 2.6% to 3.2% of DKA ... Patients with DKA ... #DKA #EDKA #Insulin
SGLT2 Inhibitors - Pharmacology Summary
Mechanisms of Action: Inhibits SGLT2 (sodium/glucose cotransporter 2) in the proximal tubule,
SGLT2 Inhibitors ... Action: Inhibits SGLT2 ... ketoacidosis (DKA ... EricsMedicalLectures/featured #SGLT2
Diabetic Ketoacidosis (DKA) - Diagnosis and Management Summary

Symptoms:
• Abdominal pain
• Nausea
• Polyuria
• Polydipsia
• Vomiting
• Weight loss
•
Ketoacidosis (DKA ... ) - Diagnosis and ... , and death DKA ... 200 mg/dL #DKA ... #Ketoacidosis #Diagnosis
DKA vs HHS
 - Think of DKA and HHS on a spectrum of hyperglycemic emergencies
 -
DKA vs HHS - Think ... of DKA and HHS ... look like overlap DKA ... BrighamChiefs #DKA ... comparison #laboratory #diagnosis
Ketosis Disorders
Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied
ketoacidosis (DKA ... • Euglycemic DKA ... • DKA/HHS Overlap ... features of both DKA ... #differential #diagnosis