13 results
Pathophysiology Euglycemic DKA - Mechanism of SGLT-2 Inhibitors #Pathophys #Endocrine #Euglycemic #DKA #SGLT2 #Mechanism
Pathophysiology Euglycemic DKA ... - Mechanism of SGLT ... Endocrine #Euglycemic #DKA ... #SGLT2 #Mechanism
SGLT2 Inhibitors and Euglycemic DKA

Risk factors for euglycemic DKA in those on an SGLT2i include:
 •
SGLT2 Inhibitors ... and Euglycemic DKA ... for euglycemic DKA ... is closed • SGLT2 ... Kat_Watson #SGLT2
Indications for and pharmacological properties of approved SGLT2 inhibitors

Canagliflozin - Dapagliflozin - Empagliflozin - Ertugliflozin

#SGLT2 #Inhibitors
properties of approved SGLT2 ... Ertugliflozin #SGLT2 ... #pharmacology #table
Stepwise Approach to Prescription of SGLT2 inhibitors 

Anticipatory Guidance 
• Consider diuretic dose reduction 
Patient Counseling
Prescription of SGLT2 ... • Symptoms Of DKA ... endocrinologists #SGLT2
Selected Clinical Trials of SGLT2 inhibitors in CVD and CKD
EMPA-REG OUTCOME - Empagliflozin lowered CV events
Clinical Trials of SGLT2 ... ASCVD; signal for SGLT2i ... risk; signal for SGLT2i ... mcclaffertyMD #SGLT2 ... visualabstract #table
Metabolic Acidosis with Anion Gap - KILU Mnemonic

K - Ketoacidosis
	• DKA
		- With normal glucose, ask if
Ketoacidosis • DKA ... glucose, ask if on SGLT2 ... ketoacidosis in SGLT2 ... inhibitors and SGLT2
Pathophysiology of Euglycemic DKA in SGLT2 Inhibitors
 • Kidney: Glycosuria, Natriuresis, ↑ Ketone bodies reabsorption
 •
of Euglycemic DKA ... in SGLT2 Inhibitors ... → Euglycemic DKA ... #Euglycemic #DKA ... #SGLT2i #Inhibitors
SGLT2 Inhibitors - Pharmacology Summary
Mechanisms of Action: Inhibits SGLT2 (sodium/glucose cotransporter 2) in the proximal tubule,
SGLT2 Inhibitors ... Action: Inhibits SGLT2 ... ketoacidosis (DKA ... EricsMedicalLectures/featured #SGLT2
Diabetes Medications Summary Table
Insulin
Lifestyle modifications
Metformin
Sulfonylureas
GLP-1 receptor agonists - ↓ major adverse CV events
TZDs
DPP-4 inhibitors
SGLT2 inhibitors -
Medications Summary Table ... -4 inhibitors SGLT2 ... #medications #table
#diabetes #T2DM #antidiabeticagents #oraldiabeticagents

FIGURE 9.1 Glucose-lowering medication in type 2 diabetes: overall approach. For appropriate context,
receptor agonist; SGLT2i ... , SGLT2 inhibitor ... MJ, D’Alessio DA