1963 results
Diabetes Combination Tablets - Estimated A1c Lowering 
Metformin + DPP4 
• Janumet (metformin + sitagliptin) 
•
Metformin + SGLT2 ... dapagliflozin) Dpp4 + SGLT2 ... Tablets #Oral #DM2
SGLT2 Inhibitors - Pharmacology Summary
Mechanisms of Action: Inhibits SGLT2 (sodium/glucose cotransporter 2) in the proximal tubule,
SGLT2 Inhibitors ... Action: Inhibits SGLT2 ... mL/minute/1.73 m2 ... EricsMedicalLectures/featured #SGLT2 ... Pharmacology #Summary #DM2
Diabetes Medications Summary Table
Insulin
Lifestyle modifications
Metformin
Sulfonylureas
GLP-1 receptor agonists - ↓ major adverse CV events
TZDs
DPP-4 inhibitors
SGLT2 inhibitors -
-4 inhibitors SGLT2 ... endocrinology #dm2
SGLT2 Inhibitors 
SGLT2 inhibitors are the newest class of anti-diabetic medications, with the first one (Canagliflozin)
SGLT2 Inhibitors ... SGLT2 inhibitors ... /ambcarerx #SGLT2 ... #Medications #DM2
Severity of Aortic Stenosis in Adults 
Current ACC/AHA guidelines recommend cut-off values for Doppler-echocardiographic measurements of
area (AVA) <1.0 cm2 ... surface area <0.6 cm2 ... /m2, mean gradient ... common problem in clinical ... combination of an AVA <1 cm2
D-Sign on Ultrasound
Right Ventricular Pressure vs Volume Overload
Eccentricity Index (EI) = D2/D1
RV Overload “D Sign” EI
Eccentricity Index (EI) = D2 ... ” EI > 1 - POCUS ... diagnosis #cardiology #pocus
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
Action, Effects, Clinical ... Acetazolamide, others SGLT2
Terry's Nails

Proximal paleness extending halfway up the nail, often eliminating the lunula. Darker distal band. Seen
cirrhosis, CHF, DM2 ... #PhysicalExam #Clinical
Selected Clinical Trials of SGLT2 inhibitors in CVD and CKD
EMPA-REG OUTCOME - Empagliflozin lowered CV events
Selected Clinical ... Trials of SGLT2 ... mcclaffertyMD #SGLT2
Type B Aortic Dissection Flap on POCUS Echocardiogram - PLAX

Elderly male with hypertension and DM presents
Dissection Flap on POCUS ... hypertension and DM ... Dissection #Flap #POCUS ... PLAX #Cardiology #clinical