20 results
Selective Publication of Antidepressant Trials

A more complete picture: contrasting the journal version of antidepressant trials with
Selective Publication ... trials with the FDA ... NEJMsa065779 #Policy #EBM ... Antidepressants #SSRIs ... #Publication #Bias
Selective Publication of Antidepressant Trials

A more complete picture: contrasting the journal version of antidepressant trials with
Selective Publication ... trials with the FDA ... NEJMsa065779 #Policy #EBM ... Antidepressants #SSRIs ... #Publication #Bias
USMLE Epidemiology and Biostatistics Summary
Meta-Analysis: pools data from several studies (greater power), limited by quality/bias of
limited by quality/bias ... increase power) Selection ... bias: nonrandom ... recall Late-look bias ... time Lead-time bias
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
PLT in selected cases ... PT, aPTT(liver disease ... bypass), LFT (liver disease ... patients if the cause ... When do you do a BM
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
Anti-dsDNA (in 70% of cases ... seen in 30—70% of cases ... connective tissue disease ... + 90% • Anti-GBM ... disease - MPO>PR3
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
Glomerular Diseases ... syndrome—due to GBM ... RBC casts in urine ... but in severe cases ... #Glomerular #Diseases
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
Cytomegalovirus; GBM ... hour collection based ... impairment), heart disease ... diagnosis cluster, the diseases ... Nephrocalcinosis causes
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
leukemias > 20% blasts ... extramedullary disease ... cells - Blood & BM ... • Cytopenia -> BM ... -> AML: Blast crises
Nail Pathologies - Findings in or Near Nails

Paronychia 

A superficial infection of the proximal and lateral
tissue at the nail base ... Local causes include ... Systemic causes ... the nail plate caused ... by defective layering
Pseudogout: pathogenesis and clinical findings
 - Idiopathic (vast majority of cases) -> Mechanism unknown
 - Familial
vast majority of cases ... Hypophosphatasia -> Defective ... Pseudogout #CPPD #Disease