108 results
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... Cell Disease Vaso-occlusive ... • XR, MRI to ... • Differentiate ... #Disease #differential
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
Pain - Diagnostic ... ), RA, crystal disease ... cutoff... >10K is ... #Joint #Pain #MSK ... approach #workup #differential
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features
 • RA affects 1% of population, women >
diseases features ... pain, swelling, ... is bilaterally ... pain), especially ... subcondral bone is
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
: Is the pain from ... Disease: • Pain ... disease must be ... necrosis, and Paget disease ... approach #workup #differential
Inflammatory Joint Pain - Differential Diagnosis Algorithm 
Monoarticular
 • Gout (Podagra, Tophi)
 • Pseudogout
 • Early
Inflammatory Joint ... Pain - Differential ... Oligoarticular (1-4 joints ... POLYARTICULAR (>4 joints ... JointPain #MSK #Differential
Distinguishing between Inflammatory and Degenerative joint disease
Inflammatory Joint Disease
 • Swelling stimulates joint nociceptors -> Pain
disease Inflammatory ... Joint Disease ... nociceptors -> Pain ... painful swelling -> Pain ... Disease • Motion
Infectious Joint Pain - Differential Diagnosis Algorithm 
Polyarticular Join Pain
 • Viral Myalgia
 • Viral Arthritis
Infectious Joint ... Pain - Differential ... Polyarticular Join ... Pain • Viral ... Lesions) • Fifth Disease
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Associated with Joint ... Pain Rash ... gangrenosum • IBD ... #pain #skin #rashes ... #differential #
Acute Joint Pain - Vitamin CD Mnemonic
Vascular
Infectious
Trauma - Multiple injury sites, Open Fracture, Infectious joint pain
Autoimmune
Acute Joint Pain ... pain Autoimmune ... pain Metabolic ... Degenerative Disc Disease ... #Orthopedics #differential
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
Differential Diagnosis ... Rheumatologic Disease ... whippleii (Whipple's disease ... burgdorferi (Lyme disease ... #pain #Differential