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management syndrome activation adult aosd apml arteritis differential differentiation disease disorders eosinophil eosinophilia essential et gca giantcell hemophilia leukostasis lysis
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Disorders Testing Algorithm ... glucocorticoid treatment ... signs or symptoms (eg ... #Differential #diagnosis ... #hematology #eosinophilia
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
- Nonremitting fever ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
hemophilia type (e.g ... by a hemophilia treatment ... Avoid meds that ... #Management #treatment ... #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- 80% have fever ... organ damage • Treatment ... unless worrisome EKG ... Syndrome #TLS #diagnosis ... #management #hematology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
• Leukocytosis Diagnosis ... Treatment - Mild ... : NSAIDS Treatment ... Prednisone 0.5-1mg/kg ... #rheumatology #
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Prednisone 5mg/kg ... Subacute-Acute: • Common: fever ... Renal Failure Treatment ... #management #hematology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Diagnosis = clinical ... Sedimentation rate (ESR or sed ... of the steroid treatment ... Treatment of GCA ... them, but urgent rheumatology
Essential Thrombocythemia (ET) ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
Splenomegaly Diagnosis ... A conclusive diagnosis ... • Treatment algorithms ... Thrombocythemia #ET #hematology ... #hematology
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