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diagnosis hyperthyroidism diabetes secondary adrenal algorithm causes diabetic diabeticketoacidosis differential feedbackloop gh glftap growthhormone hyperparathyroidism insufficiency interpretation ketoacidosis macroadenoma masseffects
Primary Hyperthyroidism - Pathogenesis and Clinical Findings Note: Although rare, gestational diseases can lead to thyrotoxicosis due
Primary Hyperthyroidism ... production by the pituitary ... Signs/Symptoms: ... Hyperthyroidism #endocrinology ... #pathophysiology
Pathogenesis and Pathophysiology of Diabetic Ketoacidosis (DKA) DKA is a result of an absolute or relative insulin
Pathogenesis and Pathophysiology ... Insulin is the primary ... details of the pathophysiology ... #Pathophysiology ... #Diabetes #Endocrinology
Primary vs Secondary Adrenal Insufficiency - Pathophysiology Primary AI = adrenal glands themselves are the problem. This
Primary vs Secondary ... Insufficiency - Pathophysiology ... Secondary AI = the pituitary ... Insufficiency #Pathophysiology ... #endocrinology
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
Pituitary Mass Effects ... Pituitary adenomas ... Signs / Symptoms ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Hyperparathyroidism - Primary vs Secondary vs Tertiary Lab Comparison: • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
Hyperparathyroidism - Primary ... Comparison: • Primary ... Symptoms: Commonly no signs ... Hyperparathyroidism #diagnosis #endocrinology ... Secondary #Tertiary #pathophysiology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... #FeedbackLoop #endocrinology ... #pathophysiology ... #pituitary
Approach to Thyroid Function Tests in the Evaluation of Hyperthyroidism • Low TSH, Low normal T4
high T4 +/- T3 → Primary ... Hyperthyroidism → Signs ... Hyperthyroidism → MRI Pituitary ... algorithm #diagnosis #endocrinology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
Ketoacidosis (DKA ... Findings • Note: in DKA ... Signs/Symptoms/Complications ... #pathophysiology ... #endocrinology
Hyperthyroidism Overview Clinical Manifestation of Hyperthyroidism: • Fatigue • Weight loss • Heat intolerance • Depression, nervousness
• Insomnia Primary ... TSH-producing pituitary ... #differential #endocrinology ... #signs #symptoms
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