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diagnosis symptoms hypothyroid 21hydroxylasedeficiency 21ohd acromegaly algorithm causes differential feedbackloop genetics gh glftap growthhormone hyperthyroid hypothyroidism interpretation macroadenoma management masseffects
Approach to Thyroid Function Tests in the Evaluation of Hyperthyroidism • Low TSH, Low normal T4
Evaluation of Hyperthyroidism ... Possibly Central Hypothyroidism ... → Signs of ... → MRI Pituitary ... algorithm #diagnosis #endocrinology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings Note: Although rare, gestational diseases can lead to thyrotoxicosis due
Primary Hyperthyroidism ... production by the pituitary ... Signs/Symptoms: ... #endocrinology ... #pathophysiology
Hypothyroidism and Hyperthyroidism - Symptoms and Signs Hypothyroidism: - General - From asymptomatic to myxedema coma, “Like
Hyperthyroidism ... - Symptoms and Signs ... retraction and lid lag ... Hyperthyroid #Symptoms #Signs ... #Diagnosis #endocrinology
Hyperthyroidism – symptoms and signs. Symptoms: Weight loss, Increased appetite, Irritability/behaviour change, Restlessness, Malaise, Stiffness, Muscle weakness,
Hyperthyroidism ... – symptoms and signs ... Exophthalmos, Lid lag ... Pretibial myxoedema #Hyperthyroidism ... #Diagnosis #Endocrinology
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
Pituitary Mass Effects ... Pituitary adenomas ... Signs / Symptoms ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Hyperthyroidism Overview Clinical Manifestation of Hyperthyroidism: • Fatigue • Weight loss • Heat intolerance • Depression, nervousness
Hyperthyroidism ... Manifestation of Hyperthyroidism ... TSH-producing pituitary ... #differential #endocrinology ... #signs #symptoms
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... #FeedbackLoop #endocrinology ... #pathophysiology ... #pituitary
Hypothyroid Myopathy Very common (up to 80% ) in patients with hypothyroidism Pathophysiology: • T4 deficiency leads to
patients with hypothyroidism ... Pathophysiology ... Hypothyroid #Myopathy #pathophysiology ... #signs #symptoms ... #endocrinology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
malignancy Pathophysiology ... pseudo-acromegaly, obesity, hypothyroidism ... • Pituitary ... Diagnosis #Management #Endocrinology ... #Treatment #Pathophysiology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology ... #peds #pediatrics
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