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diagnosis differential oncology causes algorithm generalized mds myelodysplastic pruritus rheumatology systemic activation aplastic chronic cll common cvid gap globulin hypogammaglobulinemia
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... Myelodysplastic syndrome ... Chronic myeloid leukemia ... Diagnosis #Causes #hematology ... #secondary
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
renal failure/uremia ... • Lymphoma • Leukemia ... Myelodisplastic syndrome ... Pruritus #primary #secondary ... #generalized #dermatology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... cytopenias (usually anemia ... transformation to acute leukemia ... Myelodysplastic #Syndrome ... #treatment #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
- infiltrates (anemia ... • Tumor lysis syndrome ... bone marrow and secondary ... CLL -> Invade Skin ... #Hematology #Oncology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... leakage of RBC's secondary ... - Hemolytic anemia ... Differential #Diagnosis #hematology ... #nonpalpable #dermatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... • Neutropenia, anemia ... • Richter’s Syndrome ... • Sezary syndrome ... workup #oncology #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Headaches • Pale skin ... virus (EBV) • Leukemia ... #oncology #hematology ... #diagnosis #management
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary Skin ... • Lymphoma • Leukemia ... Myelodisplastic syndrome ... #Pruritus #secondary ... #generalized #dermatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... DDX: Rule Out Secondary ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... #diagnosis #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
infection risk secondary ... autoimmune hemolytic anemia ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology
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