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diagnosis hematology leukemia chronic common differential differentiation distribution lymphocytic primarycare rash syndrome workup
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... nontender cutaneous plaques ... smear: Blasts APML ... -> Invade Skin: ... #Oncology #Diagnosis
Common Dermatological Conditions - Distribution and Morphology • Acne vulgaris - Face, upper back, chest -
• Seborrheic dermatitis ... scale • Basal cell ... • Squamous cell ... macerated areas with satellite ... ; pruritis #dermatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... macules, papules, plaques ... Transform to DLBCL, PML ... diagnosis #workup #oncology ... #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome in APML ... • Induce blast cell ... febrile neutrophilic dermatosis ... #diagnosis #management ... #hematology #oncology
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