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diagnosis hematology oncology differential bleeding causes chronic disorders eosinophilia erythematosus gap globulin history lupus lymphocytic management mds monoclonal myelodysplasia myelodysplastic
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
APML, CLL Acute ... develop leukostasis syndrome ... • Tumor lysis syndrome ... -> Invade Skin: ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune system ... Hepatomegaly • Skin ... Scoring system: ... • Richter’s Syndrome ... workup #oncology #hematology
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
Primary: - CML ... Lymphomas - Systemic ... Acute Eosinophilic Leukemia ... Hypereosinophilic Syndrome ... Diagnosis #Causes #hematology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
associated with systemic ... Musculoskeletal system ... general feeling of ill ... - Lupus - Leukemia ... #diagnosis #dermatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... Alpha & Mu) Skin ... neuropathy) • Systemic ... thrombosis+Pulm HTN+skin ... Paraproteinemias #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes ... just beneath the skin ... Chronic Myelogenous Leukemia ... Cell Leukemia ... #diagnosis #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... 3rd Decade Skin ... Non-autoimmune rheumatologic ... Seizures • Strokes Skin ... Hodgkin lymphoma and leukemia
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Lacrimal swelling • Skin ... Central nervous system ... amyloidosis, PAH Skin ... lubricants • Pharmacologic ... #Rheumatology #
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
leukemia • Solitary ... gammopathy, and skin ... changes (POEMS syndrome ... gastric tumors • Hematology ... differential #diagnosis #hematology
Helpful Clinical Features in Evaluating Bleeding Disorders Age of onset • Neonate - in 20% of haemophilias,
relatives (if all ... • Presence of systemic ... membrane bleeding and skin ... Marfan syndrome, ... pediatrics #diagnosis #hematology
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