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diagnosis differential management symptoms comparison dermatology scleroderma syndrome table vasculitis workup antimda5dm arteritis behcet causes classification cold common cvid dermatomyositis
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Systemic Sclerosis ... autoimmune disease ... thickening Signs ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Physical Exam/Signs ... Hepatomegaly • Skin ... Scoring system: ... workup #oncology #hematology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
chest (in a V-sign ... CD4+ and CD8+ T cell ... Mechanic's hands #AntiMDA5DM ... #AntiMDA5 #Dermatomyositis ... #rheumatology #
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
(vasculitis / autoimmune ... Primary: - CML ... Lymphomas - Systemic ... Hypereosinophilic Syndrome - Chronic ... Diagnosis #Causes #hematology
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
Autoimmune diseases ... trigger - Direct skin ... Atopic diseases, Chronic ... spontaneous urticaria, Chronic ... Urticaria #diagnosis #rheumatology
Scleroderma Like Conditions - Differential Diagnosis Eosinophilic Fasciitis: - Orange peel induration (peau d'orange) of proximal extremities
treatment Nephrogenic Systemic ... large numbers of stellate ... frequent in men Chronic ... hematopoietic stem cell ... comparison #table #dermatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... disease • Non-autoimmune ... rheumatologic diseases ... with Lupus: • Chronic ... Erythematosus #Diagnosis #Rheumatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... Autoimmunity • Chronic ... hemolytic anemia) • Systemic ... Malignancies • Chronic ... hypogammaglobulinemia #immunology #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... Lacrimal swelling • Skin ... Central nervous system ... Nephrogenic DI Hematologic ... Sjogrens #Syndrome #Rheumatology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Giant cell arteritis ... sx + signs/sx of ... required due to skip ... them, but urgent rheumatology ... GCA #Temporal #Signs
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