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diagnosis differential management dermatology hematology oncology symptoms comparison dermatomyositis leukemia table vasculitis antimda5dm antinxp2 antinxp2dm arteritis autoimmune behcet classification cold
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... with a relatively chronic ... (Chronic Myeloid ... -> Invade Skin: ... #Leukemia #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Physical Exam/Signs ... Hepatomegaly • Skin ... #Chronic #Lymphocytic ... workup #oncology #hematology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
chest (in a V-sign ... CD4+ and CD8+ T cell ... Mechanic's hands #AntiMDA5DM ... #AntiMDA5 #Dermatomyositis ... #rheumatology #
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
trigger - Direct skin ... 50% of patients Skin ... Atopic diseases, Chronic ... spontaneous urticaria, Chronic ... Urticaria #diagnosis #rheumatology
Scleroderma Like Conditions - Differential Diagnosis Eosinophilic Fasciitis: - Orange peel induration (peau d'orange) of proximal extremities
eosinophilia, skin ... Full-thickness skin ... large numbers of stellate ... frequent in men Chronic ... hematopoietic stem cell
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
response to local skin ... test (this is a skin ... Recurrent and chronic ... diagnosis #management #signs ... #symptoms #rheumatology
Common Dermatological Conditions - Distribution and Morphology • Acne vulgaris - Face, upper back, chest -
associated with signs ... scale • Basal cell ... on sun-damaged skin ... • Squamous cell ... macerated areas with satellite
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Pathophysiology: 1) T-cell ... and increased B-cell ... Self-limiting, chronic ... nodes: 13-15%, skin ... Diagnosis #Management #Signs
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Purpura, ischemic skin ... Eosinophilia, asthma, chronic ... - Affects the skin ... purpura: strong sign ... differential #diagnosis #rheumatology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Giant cell arteritis ... systemic sx + signs ... required due to skip ... them, but urgent rheumatology ... GCA #Temporal #Signs
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