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diagnosis comparison dermatology differential hematology leukemia oncology table antimda5dm cold dermatomyositis fungal infections infectiousdiseases management mycoses scleroderma urticaria vasculitis workup
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... (Chronic Myeloid ... (Chronic Lymphocytic ... -> Invade Skin: ... #Leukemia #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Physical Exam/Signs ... Hepatomegaly • Skin ... #Chronic #Lymphocytic ... workup #oncology #hematology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
chest (in a V-sign ... CD4+ and CD8+ T cell ... Mechanic's hands #AntiMDA5DM ... #AntiMDA5 #Dermatomyositis ... #rheumatology #
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
trigger - Direct skin ... infiltration (lymphocytes ... Atopic diseases, Chronic ... spontaneous urticaria, Chronic ... Urticaria #diagnosis #rheumatology
Scleroderma Like Conditions - Differential Diagnosis Eosinophilic Fasciitis: - Orange peel induration (peau d'orange) of proximal extremities
eosinophilia, skin ... biopsy demonstrates lymphocytes ... large numbers of stellate ... frequent in men Chronic ... hematopoietic stem cell
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... CRP GCA (Giant Cell ... elevated protein, lymphocytic ... Eosinophilia, asthma, chronic ... Differential #Diagnosis #Rheumatology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
pulmonary symptoms • Rheumatologic ... osteomyelitis or skin ... count (mainly lymphocytes ... organism into the skin ... Mouth, throat, skin
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